[HTML][HTML] Myostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy
U Moore, E Fernández-Simón, M Schiava, D Cox… - Neuromuscular …, 2023 - Elsevier
Myostatin is a myokine which acts upon skeletal muscle to inhibit growth and regeneration.
Myostatin is endogenously antagonised by follistatin. This study assessed serum myostatin
and follistatin concentrations as monitoring or prognostic biomarkers in dysferlinopathy, an
autosomal recessively inherited muscular dystrophy. Myostatin was quantified twice with a
three-year interval in 76 patients with dysferlinopathy and 38 controls. Follistatin was
quantified in 62 of these patients at the same timepoints, and in 31 controls. Correlations …
Myostatin is endogenously antagonised by follistatin. This study assessed serum myostatin
and follistatin concentrations as monitoring or prognostic biomarkers in dysferlinopathy, an
autosomal recessively inherited muscular dystrophy. Myostatin was quantified twice with a
three-year interval in 76 patients with dysferlinopathy and 38 controls. Follistatin was
quantified in 62 of these patients at the same timepoints, and in 31 controls. Correlations …