[HTML][HTML] Role of Junctin protein interactions in cellular dynamics of calsequestrin polymer upon calcium perturbation
KW Lee, JS Maeng, JY Choi, YR Lee… - Journal of Biological …, 2012 - ASBMB
Calsequestrin (CSQ), the major intrasarcoplasmic reticulum calcium storage protein,
undergoes dynamic polymerization and depolymerization in a Ca 2+-dependent manner.
However, no direct evidence of CSQ depolymerization in vivo with physiological relevance
has been obtained. In the present study, live cell imaging analysis facilitated
characterization of the in vivo dynamics of the macromolecular CSQ structure. CSQ2
appeared as speckles in the presence of normal sarcoplasmic reticulum (SR) Ca 2+ that …
undergoes dynamic polymerization and depolymerization in a Ca 2+-dependent manner.
However, no direct evidence of CSQ depolymerization in vivo with physiological relevance
has been obtained. In the present study, live cell imaging analysis facilitated
characterization of the in vivo dynamics of the macromolecular CSQ structure. CSQ2
appeared as speckles in the presence of normal sarcoplasmic reticulum (SR) Ca 2+ that …