[HTML][HTML] Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso …
BW Hounkpe, F Chenou, I de Farias Domingos… - Research and practice …, 2021 - Elsevier
Background Recent evidence suggests that generation of neutrophil extracellular traps
(NETosis), one of the components of immunothrombosis, is associated with the
pathogenesis of both venous thromboembolism and sickle cell disease (SCD). NETosis is a
complex process regulated by several proteins such as peptidyl arginine deaminase 4
(PADI4), neutrophil elastase (ELANE), and myeloperoxidase (MPO). Among these
regulators, PADI4 is responsible of histone citrullination, an essential step for NETosis …
(NETosis), one of the components of immunothrombosis, is associated with the
pathogenesis of both venous thromboembolism and sickle cell disease (SCD). NETosis is a
complex process regulated by several proteins such as peptidyl arginine deaminase 4
(PADI4), neutrophil elastase (ELANE), and myeloperoxidase (MPO). Among these
regulators, PADI4 is responsible of histone citrullination, an essential step for NETosis …