Hypercoagulability in sickle cell disease: a curious paradox
KI Ataga, EP Orringer - The American journal of medicine, 2003 - Elsevier
There is evidence of activation of both blood coagulation and platelets in sickle cell disease.
For example, plasma samples obtained in the steady state and during painful crisis
demonstrate high levels of thrombin generation, depletion of anticoagulant proteins, and
abnormal activation of the fibrinolytic system. Similarly, exposure of surface markers such as
CD62P and CD40L, along with increased circulating levels of thrombospondin, signal
platelet activation. In addition to its effects on the cleavage of fibrinogen and its ability to …
For example, plasma samples obtained in the steady state and during painful crisis
demonstrate high levels of thrombin generation, depletion of anticoagulant proteins, and
abnormal activation of the fibrinolytic system. Similarly, exposure of surface markers such as
CD62P and CD40L, along with increased circulating levels of thrombospondin, signal
platelet activation. In addition to its effects on the cleavage of fibrinogen and its ability to …
