The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays an
essential role in cell growth control. mTOR stimulates cell growth by phosphorylating p70
ribosomal S6 kinase (S6K) and eukaryote initiation factor 4E-binding protein 1 (4EBP1). The
mTOR pathway is regulated by a wide variety of cellular signals, including mitogenic growth
factors, nutrients, cellular energy levels, and stress conditions. Recent studies have
proposed several mechanisms to explain how mTOR is regulated by growth factors and …
essential role in cell growth control. mTOR stimulates cell growth by phosphorylating p70
ribosomal S6 kinase (S6K) and eukaryote initiation factor 4E-binding protein 1 (4EBP1). The
mTOR pathway is regulated by a wide variety of cellular signals, including mitogenic growth
factors, nutrients, cellular energy levels, and stress conditions. Recent studies have
proposed several mechanisms to explain how mTOR is regulated by growth factors and …