SIRT3-and FAK-mediated acetylation-phosphorylation crosstalk of NFATc1 regulates Nε-carboxymethyl-lysine-induced vascular calcification in diabetes mellitus
Z Sun, L Zhang, K Yin, G Zang, Y Qian, X Mao, L Li… - Atherosclerosis, 2023 - Elsevier
Background and aims Arterial calcification is the predictor of cardiovascular risk in diabetic
patients. N ε-carboxymethyl-lysine (CML), a toxic metabolite, is associated with accelerated
vascular calcification in diabetes mellitus (DM). However, the mechanism remains elusive.
This study aims to explore the key regulators involved in CML-induced vascular calcification
in DM. Methods We used Western blot and immuno-staining to test the expression and
localization of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) in human samples …
patients. N ε-carboxymethyl-lysine (CML), a toxic metabolite, is associated with accelerated
vascular calcification in diabetes mellitus (DM). However, the mechanism remains elusive.
This study aims to explore the key regulators involved in CML-induced vascular calcification
in DM. Methods We used Western blot and immuno-staining to test the expression and
localization of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) in human samples …
