Understanding the multifaceted role of human down syndrome kinase DYRK1A
LJ Kay, TK Smulders-Srinivasan… - Advances in protein …, 2016 - Elsevier
The dual-specificity tyrosine (Y) phosphorylation-regulated kinase DYRK1A, also known as
Down syndrome (DS) kinase, is a dosage-dependent signaling kinase that was originally
shown to be highly expressed in DS patients as a consequence of trisomy 21. Although this
was evident some time ago, it is only in recent investigations that the molecular roles of
DYRK1A in a wide range of cellular processes are becoming increasingly apparent. Since
initial knowledge on DYRK1A became evident through minibrain mnb, the Drosophila …
Down syndrome (DS) kinase, is a dosage-dependent signaling kinase that was originally
shown to be highly expressed in DS patients as a consequence of trisomy 21. Although this
was evident some time ago, it is only in recent investigations that the molecular roles of
DYRK1A in a wide range of cellular processes are becoming increasingly apparent. Since
initial knowledge on DYRK1A became evident through minibrain mnb, the Drosophila …