[HTML][HTML] Factor XI anion‐binding sites are required for productive interactions with polyphosphate
Y Geng, IM Verhamme, SA Smith, Q Cheng… - Journal of Thrombosis …, 2013 - Elsevier
Background Conversion of factor XI (FXI) to FXIa is enhanced by polymers of inorganic
phosphate (polyP). This process requires FXI to bind to polyP. Each FXIa subunit contains
anion‐binding sites (ABSs) on the apple 3 (A3) and catalytic domains that are required for
normal heparin‐mediated enhancement of FXIa inhibition by antithrombin. Aims To
determine the importance of FXI ABSs to polyP enhancement of FXI activation. Methods
Recombinant FXI variants lacking one or both ABSs were tested in polyP‐dependent …
phosphate (polyP). This process requires FXI to bind to polyP. Each FXIa subunit contains
anion‐binding sites (ABSs) on the apple 3 (A3) and catalytic domains that are required for
normal heparin‐mediated enhancement of FXIa inhibition by antithrombin. Aims To
determine the importance of FXI ABSs to polyP enhancement of FXI activation. Methods
Recombinant FXI variants lacking one or both ABSs were tested in polyP‐dependent …
