Mechanistic studies of DNase I activity: impact of heparin variants and PAD4
S Sohrabipour, VS Muniz, N Sharma, DJ Dwivedi… - Shock, 2021 - journals.lww.com
Background: Excessive production of neutrophil extracellular traps (NETs) in sepsis
contributes to vascular occlusion by acting as a scaffold and stimulus for thrombus formation.
Removal of extracellular DNA, the major structural component of NETs, by DNase I may
reduce host injury. Objectives:(1) To determine how heparin variants (unfractionated
heparin, enoxaparin, Vasoflux, and fondaparinux) affect DNase I activity,
contributes to vascular occlusion by acting as a scaffold and stimulus for thrombus formation.
Removal of extracellular DNA, the major structural component of NETs, by DNase I may
reduce host injury. Objectives:(1) To determine how heparin variants (unfractionated
heparin, enoxaparin, Vasoflux, and fondaparinux) affect DNase I activity,
Abstract
Background:
Excessive production of neutrophil extracellular traps (NETs) in sepsis contributes to vascular occlusion by acting as a scaffold and stimulus for thrombus formation. Removal of extracellular DNA, the major structural component of NETs, by DNase I may reduce host injury.
Objectives:
(1) To determine how heparin variants (unfractionated heparin, enoxaparin, Vasoflux, and fondaparinux) affect DNase I activity,
Lippincott Williams & Wilkins