Is GRP78 (Glucose-regulated protein 78) a prognostic biomarker in differents types of cancer? A systematic review and meta-analysis
NS Dos Santos, DR Gonçalves, B Balbinot… - Pathology-Research and …, 2023 - Elsevier
GRP78 is a chaperone with anti-apoptotic function associated with aggressive tumors. This
systematic review aimed to evaluate GRP78 expression in cancer and its relation to
prognosis outcomes. This review was conducted in different databases searching for human
cancer studies assessing GRP78 immunohistochemical levels on tissue samples. A total of
98 manuscripts were included. In 62% of the studies, GRP78 was associated with a worse
prognosis. A meta-analysis included 29 studies that detected a significantly higher …
systematic review aimed to evaluate GRP78 expression in cancer and its relation to
prognosis outcomes. This review was conducted in different databases searching for human
cancer studies assessing GRP78 immunohistochemical levels on tissue samples. A total of
98 manuscripts were included. In 62% of the studies, GRP78 was associated with a worse
prognosis. A meta-analysis included 29 studies that detected a significantly higher …
