Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers
A Bharthuar, AA Khorana, A Hutson, JG Wang… - Thrombosis research, 2013 - Elsevier
Background Tissue factor (TF), the physiologic initiator of coagulation, is over-expressed in
pancreatic cancer, and is associated with a pro-coagulant and pro-angiogenic state. We
hypothesized that in patients with pancreaticobiliary cancers (PBC), elevated circulating
microparticle-associated TF (MP-TF) activity would be associated with thrombosis and
worsened survival. Patients and Methods Clinical data and plasma were obtained for
consecutive patients with PBC seen at Roswell Park Cancer Institute from 2005-08. MP-TF …
pancreatic cancer, and is associated with a pro-coagulant and pro-angiogenic state. We
hypothesized that in patients with pancreaticobiliary cancers (PBC), elevated circulating
microparticle-associated TF (MP-TF) activity would be associated with thrombosis and
worsened survival. Patients and Methods Clinical data and plasma were obtained for
consecutive patients with PBC seen at Roswell Park Cancer Institute from 2005-08. MP-TF …
