cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIβ to BIG2
A Islam, H Jones, T Hiroi, J Lam, J Zhang… - Journal of biological …, 2008 - ASBMB
The 55-kDa TNFR1 (type I tumor necrosis factor receptor) can be released to the
extracellular space by two mechanisms, the proteolytic cleavage and shedding of soluble
receptor ectodomains and the release of full-length receptors within exosome-like vesicles.
We have shown that the brefeldin A-inhibited guanine nucleotide exchange protein BIG2
associates with TNFR1 and selectively modulates the release of TNFR1 exosome-like
vesicles via an ARF1-and ARF3-dependent mechanism. Here, we assessed the role of BIG2 …
extracellular space by two mechanisms, the proteolytic cleavage and shedding of soluble
receptor ectodomains and the release of full-length receptors within exosome-like vesicles.
We have shown that the brefeldin A-inhibited guanine nucleotide exchange protein BIG2
associates with TNFR1 and selectively modulates the release of TNFR1 exosome-like
vesicles via an ARF1-and ARF3-dependent mechanism. Here, we assessed the role of BIG2 …
