[HTML][HTML] Increased infections and delayed CD4+ T cell but faster B cell immune reconstitution after post-transplantation cyclophosphamide compared to conventional …
F Khimani, P Ranspach, H Elmariah, J Kim… - … and Cellular Therapy, 2021 - Elsevier
Post-transplantation cyclophosphamide (PTCy) is being increasingly used for graft-versus-
host disease (GVHD) prophylaxis after allogeneic hematopoietic cell transplantation (allo-
HCT) across various donor types. However, immune reconstitution and infection incidence
after PTCy-based versus conventional GVHD prophylaxis has not been well studied. We
evaluated the infection density and immune reconstitution (ie, absolute CD4+ T cell, CD8+ T
cell, natural killer cell, and B cell counts) at 3 months, 6 months, and 1 year post-HCT in 583 …
host disease (GVHD) prophylaxis after allogeneic hematopoietic cell transplantation (allo-
HCT) across various donor types. However, immune reconstitution and infection incidence
after PTCy-based versus conventional GVHD prophylaxis has not been well studied. We
evaluated the infection density and immune reconstitution (ie, absolute CD4+ T cell, CD8+ T
cell, natural killer cell, and B cell counts) at 3 months, 6 months, and 1 year post-HCT in 583 …
